医学
安慰剂
内科学
硫胺素
内分泌学
糖尿病
氧化应激
硫辛酸
肌肽
2型糖尿病
2型糖尿病
花生四烯酸
化学
生物化学
抗氧化剂
替代医学
酶
病理
作者
Spyridon Karkabounas,Nikolaos G. Papadopoulos,Chryssa Anastasiadou,Chrysoula Gubili,Dimitrios Peschos,Telemachos Daskalou,Nikolaos Fikioris,Yannis V. Simos,Evangelos Kontargiris,Xenophon Gianakopoulos,Vasileios Ragos,Maria Chatzidimitriou
出处
期刊:Journal of Medicinal Food
[Mary Ann Liebert]
日期:2018-12-01
卷期号:21 (12): 1197-1203
被引量:34
标识
DOI:10.1089/jmf.2018.0007
摘要
Type 2 diabetes mellitus (T2DM) is evolving to an epidemic of the modern world. T2DM is associated with a number of pathological complications, including cardiovascular disease that is mostly promoted by the increased oxidative stress in type 2 diabetic patients. We performed a randomized double-blind placebo-controlled trial to investigate the effectiveness of an individualized oral supplementation with α-lipoic acid (ALA), carnosine, and thiamine. For that purpose, 82 obese type 2 diabetic patients were randomly assigned to 2 groups, and were either supplemented daily with 7 mg ALA/kg body weight, 6 mg carnosine/kg body weight, and 1 mg thiamine/kg body weight or placebo for 8 weeks. An array of biochemical tests including the estimation of oxidative stress and platelet aggregation were performed at baseline and at follow-up. Moreover, the antiplatelet activity of each of the supplement's components was determined ex vivo at human and washed rabbit platelets. Glucose and HbA1c levels were significantly reduced after supplementation (135.7 ± 19.5 mg/dL vs. 126.5 ± 16.8 mg/dL and 8.3% ± 0.3% vs. 6.03% ± 0.58%, respectively, P < .05); however, insulin was significantly increased (3.6 ± 0.7 μIU/mL vs. 6.8 ± 0.2 μIU/mL, P < .05). The patients treated with the supplement recorded higher follow-up values for HOMA-IR and HOMA-β, and a significant drop in serum hydroperoxide level. Only ALA inhibited platelets aggregation ex vivo through ADP, platelet activating factor, arachidonic acid, epinephrine, collagen, and thrombin pathways. Daily supplementation with an individualized ALA, carnosine, and thiamine supplement effectively reduced glucose concentration in type 2 diabetic patients, probably by increasing insulin production from the pancreas. In addition to that, the reduction of oxidative stress and inhibition of platelet aggregation could potentially provide greater cardiovascular protection. Further studies are needed to fine-tune the supplementation dose–response effects in T2DM patients.
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