Studies in zebrafish annotate CNNM2 and NT5C2 as the most likely causal genes at the blood pressure locus on chromosome 10Q24.32

Aim: Genome-wide association studies (GWAS) have identified variants for high blood pressure (BP) at more than 270 loci with genome-wide significance. The locus at 10q24.32 encompasses four genes, namely AS3MT, CNNM2, CYP17A1 and NT5C2 and till date, it warrants investigation to pin down the specific gene to be responsible for the phenotype.