腙
膜
阿霉素
化学
酰肼
高分子化学
氧化还原
谷胱甘肽
药物输送
组合化学
生物物理学
有机化学
生物化学
化疗
医学
外科
生物
酶
作者
Salvatore Federico,Annalisa Martorana,Giovanna Pitarresi,Fabio Salvatore Palumbo,Calogero Fiorica,Gaetano Giammona
出处
期刊:Biomaterials advances
日期:2022-03-19
卷期号:136: 212769-212769
被引量:5
标识
DOI:10.1016/j.bioadv.2022.212769
摘要
In this work, redox-sensitive polyurethane urea (PUU) based electrospun membranes have been exploited to chemically tether a pH-sensitive doxorubicin derivative achieved by linking a lipoyl hydrazide to the drug via a hydrazone linkage. First, the lipoyl-hydrazone-doxorubicin derivative labelled as LA-Hy-Doxo has been synthesized and characterized. Then, the molecule has been tethered, via a thiol-disulfide exchange reaction, to the redox-sensitive PUU (PolyCEGS) electrospun membrane. The redox-sensitive PolyCEGS PUU has been produced by using PCL-PEG-PCL polyol and glutathione-tetramethyl ester (GSSG-OMe)4 as a chain extender. The LA-Hy-Doxo tethered electrospun membrane has showed a dually controlled release triggered by acidic and reducing conditions, producing a significant cytotoxic effect in human breast cancer cell lines (MCF-7) which has validated the system for the post-surgical treatment of solid tumors to contrast recurrence.
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