后脑
斑马鱼
胚胎
畸形学
邻苯二甲酸盐
神经毒性
菱形
生物
细胞生物学
化学
解剖
内科学
毒性
遗传学
医学
胎儿
怀孕
转录因子
基因
Hox基因
有机化学
作者
Evelyn Paquette,Naomi Mumper,Alissa Rodrigues,Morgan Voulo,Sierrah Rich,Nicole M. Roy
标识
DOI:10.1016/j.ntt.2022.107093
摘要
Di-butyl phthalate (DBP) is a globally used plasticizer found in alarmingly high concentrations in soil and water ecosystems. As phthalates are non-covalently bound to plastic polymers, phthalates easily leach into the aquatic environment. The effects of DBP on aquatic organisms is concerning, most notably, studies have focused on the endocrine-disrupting effects. However, reports on the developmental neurotoxicity of DBP are rare. Using the zebrafish vertebrate model system, we treated pre-gastrulation staged embryos with 2.5 μM DBP, a concentration environmentally noted. We find that general hindbrain structure and rhombomere patterning is disrupted at 72 h post fertilization (hpf). We investigated hindbrain specific neural patterning of cranial motor neurons and find defects in branchiomotor neuron patterning and migration. Furthermore, defects in r4 specific Mauthner neuron development were also noted. Thus, we conclude that DBP exposure during embryonic development induces defects to the hindbrain and concomitantly the neurons that are born and differentiate there.
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