Oligosaccharide and short-chain fatty acid: A double-edged sword in obese mice by regulating food intake and fat synthesis

丁酸盐 食欲 化学 卡路里 内分泌学 肥胖 短链脂肪酸 生物化学 食品科学 发酵 生物
作者
Kaiyang Chen,Meimei Hu,Ming Tang,Congcong Gao,Haikuan Wang,Shuli Man,Fuping Lu
出处
期刊:Food Research International [Elsevier]
卷期号:159: 111619-111619 被引量:13
标识
DOI:10.1016/j.foodres.2022.111619
摘要

Dietary fiber has been used to prevent obesity by regulating the intestinal flora and promoting the production of short-chain fatty acids (SCFAs). However, it is insufficient to conclude the decisive role of microbiota and SCFAs by adding oligosaccharides to foods without caloric balance. In this study, the effects of oligosaccharides and their regulated microflora on the development of obesity in mice were studied by designing a high-fat diet with equal calories but different contents of oligosaccharides. Isocaloric diets demonstrated that appropriate rather than excess oligosaccharides prevent obesity by regulating appetite. Such an appetite was inhibited by oligosaccharides but promoted by SCFAs. Furthermore, promoted appetite was tightly related to decreased insulin and increased acyl-CoA binding protein, which was correlated with SCFA-induced fat degradation. Interestingly, drinking butyrate alleviated obesity even with higher calorie intake. Molecular docking demonstrated that conversion of butyrate to butyryl-CoA converted from butyrate, as a structural analog of acetyl-CoA, inhibits the activity of acetyl-CoA carboxylase. Together, these findings demonstrate that fermentable fiber supplements may have limits in obesity treatment, and we provide possible obesity therapeutic targets that inhibit bacterial fermentation or increase the ratio of butyrate/acetate.
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