Tubal abortions but not viable tubal pregnancies are characterized by an increased number of CD8 + T cells

男科 CD8型 CD20 CD3型 滋养层 细胞角蛋白 生物 免疫系统 川地68 免疫学 怀孕 医学 免疫组织化学 胎盘 胎儿 遗传学
作者
Birgit Kemp,S. Rimbach,Ulrike Kämmerer,Werner Rath,Henning M. Beier,Ulrike von Rango
出处
期刊:Journal of Reproductive Immunology [Elsevier BV]
卷期号:73 (2): 180-187 被引量:3
标识
DOI:10.1016/j.jri.2006.07.003
摘要

To examine immune cell phenotypes in viable tubal pregnancies (VTP) and in tubal abortions (TA).Paraffin-embedded specimens of VTP (n=7) and ongoing TA (n=6) were double-stained for cytokeratin for trophoblast as well as for CD45, CD3, CD8, CD68 and CD20 for immune cell phenotypes. In all cases, the amniotic sac was detected by ultrasound. Histological examination showed no evidence of necrosis within the tissues included in this study. Quantification of the subpopulations was performed in each slide by two independent examiners in five areas (0.085 mm2 each) of the invasion zone as marked by cytokeratin-positive stromal extravillous trophoblast (EVT) cells. For statistical analysis, the non-parametric two-tailed t-test was used (p<0.05).The differences in the number of CD45(+), CD68(+) and CD20(+) cells was significant (p=0.0423, p=0.0469 and p=0.0494, respectively); however, the number of CD3(+), and among those the number of CD8(+) cells, was approximately eight-fold higher in TA than in VTP (p<0.0001 and p=0.0012, respectively).The unequal distribution of CD8(+) cells in VTP and TA suggests a significant role of this immune cell phenotype in the further outcome of a tubal pregnancy either to an abortive or a viable, potentially life-threatening, entity.
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