Lithium Carbonate: A Clinical Study

Lithium carbonate has been widely acclaimed as a useful drug in the treatment of manic-depressive psychoses. The results of this clinical study emphasize that lithium is highly beneficial in preventing and alleviating acute mania and the hypomanic aspects of schizo-affective psychoses. When used alone, lithium was found to be relatively ineffective as an antidepressant. However, in combination with a tricyclic or MAO-inhibiting antidepressant, it was often effective in alleviating depressions, including those refractory to single psychopharmacological agents.