作者
Carolyn D. Dzierba,Yingzhi Bi,Bireshwar Dasgupta,Richard A. Hartz,Vijay T. Ahuja,Giovanni Cianchetta,Godwin Kumi,Li Dong,Saadat Aleem,Cynthia A. Fink,Yudith Garcia,Michael Green,Jianxin Han,Soojin Kwon,Ying Qiao,Jiancheng Wang,Yulian Zhang,Ying Liu,Greg Zipp,Zhi Liang,Neil T. Burford,Meredith Ferrante,Robert Bertekap,Martin Lewis,Angela Cacace,James E. Grace,Alan Wilson,Amr Nouraldeen,Ryan S. Westphal,David B. Kimball,Kenneth G. Carson,Joanne J. Bronson,John E. Macor
摘要
Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of phenylglycinol and phenylamine analogs have been prepared and evaluated for their GPR88 agonist activity and pharmacokinetic (PK) properties.