医学
肝细胞癌
经皮
闭塞
放射科
肝硬化
血管造影
烧蚀
外科
内科学
作者
Sandro Rossi,F Garbagnati,Riccardo Lencioni,Hans-Peter Allgaier,Alfonso Marchianò,Fabio Fornari,Pietro Quaretti,Giuseppe Di Tolla,Claudia Ambrosi,Vincenzo Mazzaferro,Hubert E. Blum,Carlo Bartolozzi
出处
期刊:Radiology
[Radiological Society of North America]
日期:2000-10-01
卷期号:217 (1): 119-126
被引量:480
标识
DOI:10.1148/radiology.217.1.r00se02119
摘要
To evaluate the usefulness of percutaneous radio-frequency (RF) thermal ablation of nonresectable hepatocellular carcinoma (HCC) after occlusion of the tumor arterial supply.Sixty-two patients with cirrhosis and biopsy-proved HCC underwent RF ablation after interruption of the tumor arterial supply by means of occlusion of either the hepatic artery with a balloon catheter (40 patients) or the feeding arteries with gelatin sponge particles (22 patients).After a single RF procedure in 56 patients and after two procedures in six patients, spiral computed tomography (CT) demonstrated a nonenhancing area corresponding in shape to the previously identified HCC, which was suggestive of complete necrosis. No major complications occurred. Two patients subsequently underwent surgical resection; the remaining 60 patients were followed up with spiral CT. During a mean follow-up of 12.1 months, 11 HCC nodules showed areas of local progression; 49 were identified as nonenhancing areas with a 40%-75% reduction in maximum diameter. The 1-year estimate of failure risk was 19% for local recurrence and 45% for overall intrahepatic recurrence. The estimated 1-year survival was 87%. Histopathologic analysis of one autopsy and two surgical specimens revealed more than 90% necrosis in one specimen and 100% necrosis in two.HCC nodules 3.5-8.5 cm in diameter can be ablated in one or two RF sessions after occlusion of the tumor arterial supply.
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