秆
Notch信号通路
萌芽血管生成
细胞生物学
血管生成
生物
表型
细胞
细胞信号
信号转导
基因
新生血管
遗传学
园艺
作者
Rosa Blanco,Holger Gerhardt
出处
期刊:Cold Spring Harbor Perspectives in Medicine
[Cold Spring Harbor Laboratory]
日期:2012-10-19
卷期号:3 (1): a006569-a006569
被引量:470
标识
DOI:10.1101/cshperspect.a006569
摘要
Sprouting angiogenesis is a dynamic process in which endothelial cells collectively migrate, shape new lumenized tubes, make new connections, and remodel the nascent network into a hierarchically branched and functionally perfused vascular bed. Endothelial cells in the nascent sprout adopt two distinct cellular phenotypes--known as tip and stalk cells--with specialized functions and gene expression patterns. VEGF and Notch signaling engage in an intricate cross talk to balance tip and stalk cell formation and to regulate directed tip cell migration and stalk cell proliferation. In this article, we summarize the current knowledge and implications of the tip/stalk cell concepts and the quantitative and dynamic integration of VEGF and Notch signaling in tip and stalk cell selection.
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