Elevation in anti-Proteus antibodies in patients with rheumatoid arthritis from Bermuda and England.

医学 奇异变形杆菌 变形杆菌 类风湿性关节炎 抗体 效价 抗体效价 内科学 免疫学 胃肠病学 金黄色葡萄球菌 大肠杆菌 细菌 生物 基因 生物化学 遗传学
作者
H Subair,Harmale Tiwana,Mark D. Fielder,Allan Binder,Kevin Y. Cunningham,Alan Ebringer,CR Wilson,Michael J. Hudson
出处
期刊:PubMed 卷期号:22 (10): 1825-8 被引量:38
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摘要

To determine whether patients with rheumatoid arthritis (RA) from Bermuda and England have an increased anti-Proteus antibody titer when compared to healthy Bermudian and English controls, and to ascertain whether any increase in antibody titer is specific by testing 4 other microbes, Escherichia coli and 3 normal anaerobic bowel bacteria.Antibody titers were measured by ELISA and indirect immunofluorescence (IIFA) under coded conditions.Elevated titers of anti-Proteus antibodies were demonstrated in 34 patients with active RA from Bermuda when compared to 33 healthy Bermudian controls by ELISA (p < 0.001) and IIFA (p < 0.001). An elevation of anti-Proteus antibodies was also observed in 34 patients with RA from England when compared to 30 healthy English controls again by ELISA (p < 0.001). A similar antibody elevation in 31 patients with RA from England was observed when compared to 30 healthy controls when measured by IIFA (p < 0.001). However, there was no significant elevation in antibody titers against E. coli or the 3 normal bowel flora isolates in the patients with RA from both countries compared to their respective controls, when measured by ELISA.A specific elevation in the immune response to Proteus mirabilis has been demonstrated in patients with RA from both Bermuda and England. However, this study cannot distinguish between antibody association with disease per se and association with disease activity. The role of Proteus in RA and the effect of anti-Proteus therapy in patients with RA merits further study.

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