Meta-analysis: Diagnostic Accuracy of Anti–Cyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis

医学 类风湿性关节炎 类风湿因子 自身抗体 诊断试验中的似然比 内科学 抗体 荟萃分析 胃肠病学 免疫学 关节炎
作者
Kunihiro Nishimura,Daisuke Sugiyama,Yoshinori Kogata,Goh Tsuji,Takashi Nakazawa,Seiji Kawano,Katsuyasu Saigo,Akio Morinobu,M. Koshiba,Karen M. Kuntz,Isao Kamae,Shunichi Kumagai
出处
期刊:Annals of Internal Medicine [American College of Physicians]
卷期号:146 (11): 797-797 被引量:791
标识
DOI:10.7326/0003-4819-146-11-200706050-00008
摘要

Rheumatoid factor (RF) and autoantibodies against cyclic citrullinated peptide (CCP) are markers that might help physicians diagnose rheumatoid arthritis.To determine whether anti-CCP antibody more accurately identifies patients with rheumatoid arthritis and better predicts radiographic progression than does RF.MEDLINE through September 2006 and reference lists of retrieved studies and review articles.Studies in any language that enrolled at least 10 participants and that examined the role of anti-CCP antibody and RF in the diagnosis or prognosis of known or suspected rheumatoid arthritis.Two authors independently evaluated studies for inclusion, rated methodological quality, and abstracted relevant data.The DerSimonian-Laird random-effects method was used to summarize sensitivities, specificities, and positive and negative likelihood ratios from 37 studies of anti-CCP antibody and 50 studies of RF. The pooled sensitivity, specificity, and positive and negative likelihood ratios for anti-CCP antibody were 67% (95% CI, 62% to 72%), 95% (CI, 94% to 97%), 12.46 (CI, 9.72 to 15.98), and 0.36 (CI, 0.31 to 0.42), respectively. For IgM RF, the values were 69% (CI, 65% to 73%), 85% (CI, 82% to 88%), 4.86 (CI, 3.95 to 5.97), and 0.38 (CI, 0.33 to 0.44). Likelihood ratios among IgM RF, IgG RF, and IgA RF seemed to be similar. Results from studies of patients with early rheumatoid arthritis were similar to those from all studies. Three of 4 studies found that risk for radiographic progression was greater with anti-CCP antibody positivity than with IgM RF positivity.Many studies had methodological limitations. Studies of RF were heterogeneous and had wide ranges of sensitivity and specificity.Anti-CCP antibodies are more specific than RF for diagnosing rheumatoid arthritis and may better predict erosivedisease.
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