材料科学
放射治疗
癌症研究
光热治疗
体外
骨癌
骨转移
生物医学工程
体内
化学
癌症
医学
骨肉瘤
内科学
纳米技术
生物
转移
生物化学
生物技术
作者
Yitong Wang,Jian Yang,Hongmei Liu,Xinyu Wang,Zhengjie Zhou,Quan Huang,Dianwen Song,Xiaopan Cai,Lin Li,Kaili Lin,Jianru Xiao,Peifeng Liu,Qiang Zhang,Yiyun Cheng
出处
期刊:Biomaterials
[Elsevier]
日期:2016-11-09
卷期号:114: 97-105
被引量:66
标识
DOI:10.1016/j.biomaterials.2016.11.010
摘要
The treatment of bone tumors is a challenging problem due to the inefficient delivery of therapeutics to bone and the bone microenvironment-associated tumor resistance to chemo- and radiotherapy. Here, we developed a bone-targeted nanoparticle, aspartate octapeptide-modified dendritic platinum-copper alloy nanoparticle (Asp-DPCN), for photothermal therapy (PTT) of bone tumors. Asp-DPCN showed much higher affinity toward hydroxyapatite and bone fragments than the non-targeted DPCN in vitro. Furthermore, Asp-DPCN accumulated more efficiently around bone tumors in vivo, and resulted in a higher temperature in bone tumors during PTT. Finally, Asp-DPCN-mediated PTT not only efficiently depressed the tumor growth but also significantly reduced the osteoclastic bone destruction. Our study developed a promising therapeutic approach for the treatment of bone tumors.
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