溃疡性结肠炎
固有层
炎症性肠病
结肠炎
微生物群
炎症
免疫学
外周血单个核细胞
医学
疾病
胃肠病学
生物
内科学
病理
生物信息学
上皮
体外
生物化学
作者
Kozue Takeshita,Shinta Mizuno,Yohei Mikami,Tomohisa Sujino,Keiichiro Saigusa,Katsuyoshi Matsuoka,Makoto Naganuma,Tadashi Sato,Toshihiko Takada,Hirokazu Tsuji,Akira Kushiro,Koji Nomoto,Takanori Kanai∥
出处
期刊:Inflammatory Bowel Diseases
[Oxford University Press]
日期:2016-12-01
卷期号:22 (12): 2802-2810
被引量:126
标识
DOI:10.1097/mib.0000000000000972
摘要
BackgroundImbalance of the intestinal microbiota is associated with gastrointestinal disease and autoimmune disease and metabolic syndrome. Analysis of the intestinal microbiota has recently progressed, and the association with inflammatory bowel disease has been reported at the species level. Such findings suggest that the recovery of homeostasis in the intestinal microbiota could cure inflammatory bowel disease. We aimed to search new probiotic candidates for inflammatory bowel disease through translational research by analysis of ulcerative colitis (UC) patients' intestinal microbiota and clarify the effects of them on inflammation. Here, we focused on Fusicatenibacter saccharivorans, which belongs to Clostridium subcluster XIVa and was successfully isolated and cultured in 2013. We analyzed the association of F. saccharivorans to UC patients' activity and inflammation for the first time.
科研通智能强力驱动
Strongly Powered by AbleSci AI