细胞激素风暴
急性肾损伤
医学
药品
炎症
槲皮素
冠状病毒
发病机制
肾
氧化应激
2019年冠状病毒病(COVID-19)
抗病毒药物
药理学
疾病
免疫学
传染病(医学专业)
内科学
生物
抗氧化剂
生物化学
作者
Lúcio Ricardo Leite Diniz,Marília Trindade de Santana Souza,Allana Brunna Sucupira Duarte,Damião Pergentino de Sousa
出处
期刊:Molecules
[MDPI AG]
日期:2020-12-07
卷期号:25 (23): 5772-5772
被引量:37
标识
DOI:10.3390/molecules25235772
摘要
The inflammatory mediator and oxidant agent storm caused by the SARS-CoV-2 infection has been strongly associated with the failure of vital organs observed in critically ill patients with coronavirus disease 2019 (COVID-19) and the death of thousands of infected people around the world. Acute kidney injury (AKI) is a common renal disorder characterized by a sudden and sustained decrease in renal function with a critical influence on poor prognosis and lethal clinical outcomes of various etiologies, including some viral infection diseases. It is known that oxidative stress and inflammation play key roles in the pathogenesis and development of AKI. Quercetin is a natural substance that has multiple pharmacological properties, such as anti-inflammatory action, and is used as a dietary supplement. There is evidence of the anti-coronavirus activities of this compound, including against the target SARS-CoV-2 3CLpro. The ability to inhibit coronavirus and its inflammatory processes is strongly desired in a new drug for the treatment of COVID-19. Therefore, in this review, the dual effect of quercetin is discussed from a mechanistic perspective in relation to AKI kidney injury and its nephroprotective potential to SARS-CoV-2 patients.
科研通智能强力驱动
Strongly Powered by AbleSci AI