已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Frequency and prognostic impact of right ventricular involvement in acute myocardial infarction

医学 心脏病学 内科学 狼牙棒 心肌梗塞 射血分数 经皮冠状动脉介入治疗 梗塞 心力衰竭
作者
Thomas Stiermaier,Sören J. Backhaus,Jonas Matz,Alexander Koschalka,Johannes T. Kowallick,Suzanne de Waha‐Thiele,Steffen Desch,Matthias Gutberlet,Gerd Hasenfuß,Holger Thiele,Ingo Eitel,Andreas Schuster
出处
期刊:Heart [BMJ]
卷期号:107 (7): 563-570 被引量:15
标识
DOI:10.1136/heartjnl-2020-317184
摘要

Objective Right ventricular (RV) involvement complicating myocardial infarction (MI) is thought to impact prognosis, but potent RV markers for risk stratification are lacking. Therefore, the aim of this trial was to assess the frequency and prognostic implications of concomitant structural and functional RV injury in MI. Methods Cardiac magnetic resonance (CMR) was performed in 1235 patients with MI (ST-elevation myocardial infarction: n=795; non-STEMI: n=440) 3 days after reperfusion by primary percutaneous coronary intervention. Central core laboratory-masked analyses included structural (oedema representing reversible ischaemia, irreversible infarction, microvascular obstruction (MVO)) and functional (ejection fraction, global longitudinal strain (GLS)) RV alterations. The clinical end point was the 12-month rate of major adverse cardiac events (MACE). Results RV ischaemia and infarction were observed in 19.6% and 12.1% of patients, respectively, suggesting complete myocardial salvage in one-third of patients. RV ischaemia was associated with a significantly increased risk of MACE (10.1% vs 6.2%; p=0.035), while patients with RV infarction showed only numerically increased event rates (p=0.075). RV MVO was observed in 2.4% and not linked to outcome (p=0.894). Stratification according to median RV GLS (10.2% vs 3.8%; p<0.001) but not RV ejection fraction (p=0.175) resulted in elevated MACE rates. Multivariable analysis including clinical and left ventricular MI characteristics identified RV GLS as an independent predictor of outcome (HR 1.05, 95% CI 1.00 to 1.09; p=0.034) in addition to age (p=0.001), Killip class (p=0.020) and left ventricular GLS (p=0.001), while RV ischaemia was not independently associated with outcome. Conclusions RV GLS is a predictor of postinfarction adverse events over and above established risk factors, while structural RV involvement was not independently associated with outcome.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
Jeongin发布了新的文献求助10
3秒前
4秒前
可乐不加冰完成签到,获得积分10
8秒前
香蕉觅云应助尊敬的芷卉采纳,获得10
8秒前
Star发布了新的文献求助10
9秒前
深情安青应助tyughi采纳,获得10
10秒前
RoyYoung完成签到 ,获得积分10
10秒前
快乐的寄容完成签到 ,获得积分10
10秒前
xns完成签到,获得积分20
10秒前
11秒前
13秒前
15秒前
马丽完成签到,获得积分10
15秒前
longlong发布了新的文献求助10
17秒前
zwz发布了新的文献求助10
17秒前
郝好完成签到 ,获得积分10
17秒前
cqsjy发布了新的文献求助30
18秒前
马丽发布了新的文献求助10
19秒前
20秒前
xqy发布了新的文献求助10
21秒前
SciGPT应助Star采纳,获得10
21秒前
21秒前
隐形曼青应助物理幽灵采纳,获得10
22秒前
老姚完成签到,获得积分10
22秒前
阿飞发布了新的文献求助10
24秒前
24秒前
27秒前
Jasper应助乐乐采纳,获得10
27秒前
asuit发布了新的文献求助10
29秒前
DreamLly应助牟翎采纳,获得40
31秒前
31秒前
w1x2123发布了新的文献求助10
34秒前
34秒前
Hello应助会科研的胡萝卜采纳,获得10
38秒前
晚朝发布了新的文献求助10
38秒前
城辰发布了新的文献求助10
40秒前
43秒前
45秒前
领导范儿应助哇哈哈采纳,获得10
45秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3256703
求助须知:如何正确求助?哪些是违规求助? 2898812
关于积分的说明 8302592
捐赠科研通 2568036
什么是DOI,文献DOI怎么找? 1394855
科研通“疑难数据库(出版商)”最低求助积分说明 652913
邀请新用户注册赠送积分活动 630631