封锁
免疫疗法
免疫检查点
黑色素瘤
医学
促炎细胞因子
癌症研究
自噬
免疫系统
癌症免疫疗法
T细胞
PD-L1
免疫学
炎症
生物
受体
内科学
细胞凋亡
生物化学
作者
Bassam Janji,Meriem Hasmim,Santiago Parpal,Guy Berchem,Muhammad Zaeem Noman
出处
期刊:OncoImmunology
[Informa]
日期:2020-01-01
卷期号:9 (1)
被引量:26
标识
DOI:10.1080/2162402x.2020.1809936
摘要
Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration. In our recent report published in Science Advances, we demonstrate that targeting the autophagy-related protein Vps34 switched cold immune desert tumors into hot inflamed immune-infiltrated tumors and enhanced the efficacy of anti-PD-1/PD-L1. Our study provides the preclinical rationale to set up combination immunotherapy clinical trials using selective Vps34 inhibitors and immune checkpoint blockers in melanoma and CRC.
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