Epicardial course of the septopulmonary bundle: Anatomical considerations and clinical implications for roof line completion

医学 烧蚀 心房颤动 屋顶 导管消融 捆绑 直线(几何图形) 心脏病学 解剖 内科学 几何学 数学 结构工程 工程类 复合材料 材料科学
作者
Thomas Pambrun,Josselin Duchâteau,Anaïs Delgove,Arnaud Denis,Marion Constantin,F. Daniel Ramirez,Rémi Chauvel,Romain Tixier,Nicolas Welté,Clémentine Andre,Takashi Nakashima,Yosuke Nakatani,Tsukasa Kamakura,Takamitsu Takagi,Philipp Krisai,Ghassen Cheniti,Konstantinos Vlachos,Félix Bourier,Masateru Takigawa,Τakeshi Kitamura,Antonio Frontera,Frédéric Sacher,Mélèze Hocini,Pierre Jaı̈s,Michel Haı̈ssaguerre,Richard D. Walton,Nicolas Derval
出处
期刊:Heart Rhythm [Elsevier]
卷期号:18 (3): 349-357 被引量:82
标识
DOI:10.1016/j.hrthm.2020.11.008
摘要

Background Gaps in the roof line have been ascribed to epicardial conduction using the septopulmonary bundle. Objectives We sought to evaluate the frequency of septopulmonary bundle bypass during roof line ablation, to describe anatomical conditions favoring this epicardial gap, and to propose an alternative strategy when present. Methods One hundred consecutive patients underwent atrial fibrillation ablation. A de novo roof line was created between the superior pulmonary veins. In cases of residual gaps, a floor line was created between the inferior pulmonary veins. Microtomography imaging and histological analyses of 5 human donor hearts were performed: a specific focus was made on the dome and the posterior wall. Results Residual gaps were more frequent in roof lines than floor lines (33% vs 15%; P = .049). Electrogram morphologies, activation sequences, and pacing maneuvers indicated an epicardial bypass of the roof line in all cases. Conduction block was obtained in 67 roof lines and 28 floor lines, resulting in a 95% success rate of linear block, without “box” isolation. Between the superior pulmonary veins, the atrial myocardium was thicker and consistently displayed adipose tissue separating the septopulmonary bundle from the septoatrial bundle. Conclusion Epicardial conduction across the roof line is common and requires careful electrogram analysis to detect. In such cases, a floor line can be an effective alternative strategy, with clear validation criteria. Myocardial thickness and fat interposition may explain difficulties in achieving lesion transmurality during roof line ablation. Gaps in the roof line have been ascribed to epicardial conduction using the septopulmonary bundle. We sought to evaluate the frequency of septopulmonary bundle bypass during roof line ablation, to describe anatomical conditions favoring this epicardial gap, and to propose an alternative strategy when present. One hundred consecutive patients underwent atrial fibrillation ablation. A de novo roof line was created between the superior pulmonary veins. In cases of residual gaps, a floor line was created between the inferior pulmonary veins. Microtomography imaging and histological analyses of 5 human donor hearts were performed: a specific focus was made on the dome and the posterior wall. Residual gaps were more frequent in roof lines than floor lines (33% vs 15%; P = .049). Electrogram morphologies, activation sequences, and pacing maneuvers indicated an epicardial bypass of the roof line in all cases. Conduction block was obtained in 67 roof lines and 28 floor lines, resulting in a 95% success rate of linear block, without “box” isolation. Between the superior pulmonary veins, the atrial myocardium was thicker and consistently displayed adipose tissue separating the septopulmonary bundle from the septoatrial bundle. Epicardial conduction across the roof line is common and requires careful electrogram analysis to detect. In such cases, a floor line can be an effective alternative strategy, with clear validation criteria. Myocardial thickness and fat interposition may explain difficulties in achieving lesion transmurality during roof line ablation.
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