链脲佐菌素
医学
糖尿病
内科学
抗氧化剂
内分泌学
腹腔注射
内皮功能障碍
生理盐水
收缩性
链脲佐菌素
化学
生物化学
作者
Buket Demirci,Ömer Demir,Turhan Dost,Mustafa Birincioğlu
出处
期刊:Bratislavské lekárske listy
日期:2014-01-01
卷期号:115 (04): 190-196
被引量:31
摘要
This study investigated whether Dexpanthenol (DEX) improves diabetic cardiovascular function and cardiac performance by regulating total oxidant and antioxidant status.Diabetes was induced by a single intraperitoneal injection of Streptozocin (50 mg/kg in 1 ml of saline) and treatment groups received DEX (300 mg/kg/day) for 6 weeks. Endothelium (in)dependent relaxation responses were assessed in thoracic aortic rings and coronary vasculature together with alpha receptor and voltage dependant contractile responses of aorta. Myocardial contractility has been recorded by an intra ventricular latex balloon. Total oxidant and antioxidant status were measured from the serum samples.Induction of diabetes resulted in an apparent body weight loss, high blood glucose, endothelial dysfunction and increased serum oxidant status. DEX supplementation restored the endothelial dysfunction, antioxidant status and body weight whereas decreasing blood glucose level.Along with the standard therapy of diabetes, DEX can be used as a safe and economical way of adjuvant therapy to diminish the burden of the disease (Tab. 3, Fig. 3, Ref. 30).
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