胎盘
甲基化
DNA甲基化
生物
计算生物学
怀孕
遗传学
胎儿
基因
基因表达
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-02-04
卷期号:351 (6273): 572-573
标识
DOI:10.1126/science.351.6273.572-d
摘要
DNA Methylation
The trophoblast cells of a developing embryo give rise to extra-embryonic tissues that support embryonic growth, such as the placenta. The epigenetic modification DNA methylation is critical for the regulation of embryonic development. Branco et al. show that maternal DNA methylation also plays a role in trophoblast development. DAN methylation is required for the regulation of genes involved in cell adhesion and migration, processes required for proper placental formation that are perturbed in placental disorders such as pre-eclampsia.
Dev. Cell 10.1016/j.devcel.2015.12.027 (2015).
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