生物
再生(生物学)
间质细胞
细胞生物学
间充质干细胞
细胞外基质
祖细胞
功能(生物学)
多能干细胞
干细胞
结缔组织
癌症研究
遗传学
作者
H. S. Soliman,Marine Théret,R. Wilder Scott,Lesley A. Hill,T. Michael Underhill,Boris Hinz,Fábio Rossi
出处
期刊:Cell Stem Cell
[Elsevier]
日期:2021-10-01
卷期号:28 (10): 1690-1707
被引量:90
标识
DOI:10.1016/j.stem.2021.09.001
摘要
Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and regeneration of most tissues. They can differentiate along multiple connective lineages, but unlike most other stem/progenitor cells, they carry out various other functions while maintaining their developmental potential. MSCs function as damage sensors, respond to injury by fostering regeneration through secretion of trophic factors as well as extracellular matrix (ECM) molecules, and contribute to fibrotic reparative processes when regeneration fails. Tissue-specific MSC identity, fate(s), and function(s) are being resolved through fate mapping coupled with single cell “omics,” providing unparalleled insights into the secret lives of tissue-resident MSCs.
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