脑血流
2型糖尿病
糖化血红素
痴呆
医学
默认模式网络
内科学
脑灌注压
认知
糖尿病
心脏病学
灌注
2型糖尿病
内分泌学
精神科
疾病
作者
Wei Wang,Lin Sun,Guangyu He,Xiaokun Gang,Xue Zhao,Guixia Wang,Guang Ning
标识
DOI:10.1016/j.yfrne.2021.100916
摘要
Type 2 diabetes mellitus (T2DM) is related to abnormal brain structure and function, increasing the risk of cognitive impairment and dementia. We systematically reviewed the published literature focusing on cerebral perfusion in patients with T2DM. Although no significant difference was found in global cerebral blood flow (CBF) between the T2DM group and the healthy control group, the regional cerebral perfusion in T2DM was significantly reduced in multiple locations, including the occipital lobe, domains involved in the default mode network and the cerebellum. The decline in regional CBF was associated with a wide range of cognitive disorders in T2DM, including learning, memory, attention, and executive processing, as well as visual function. In addition, diabetes-related biochemical indicators, such as glycated hemoglobin and insulin resistance, were negatively correlated with regional CBF. In general, these functional perfusion imaging studies indicate that decreased CBF in T2DM may be a potential cause of cognitive impairment.
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