Organocatalytic, enantioselective synthesis of benzoxaboroles via Wittig/oxa-Michael reaction Cascade of α-formyl boronic acids

An enantioselective synthesis of 3-substituted benzoxaboroles has been developed using organocatalysts with good to excellent enantioselectivities (up to 99%). The resulting benzoxaboroles were converted to the chiral β-hydroxy ketones without affecting the enantioselectivity.