A Comprehensive Review on the Biological and Pharmacological Activities of Rhodanine Based Compounds for Research and Development of Drugs

罗丹宁 药效团 药品 药物发现 药理学 医学 组合化学 化学 计算生物学 生物化学 生物
作者
Jiachun Liu,Yanling Wu,Hu‐Ri Piao,Xiangfu Zhao,Wen Zhang,Yanli Wang,Minrui Liu
出处
期刊:Mini-reviews in Medicinal Chemistry [Bentham Science]
卷期号:18 (11): 948-961 被引量:12
标识
DOI:10.2174/1389557516666160928162724
摘要

At present, diseases resulting from various reasons have been causing deadly fears to humans and previously incogitable losses to health. Meanwhile, the patient compliance has been weakening because of drug resistance and serious drug adverse effects. There is therefore an urgent need for the development of novel structural agents. Rhodanine derivatives have exhibited wide biological activities, as well as significant industrial applications, which suggests that rhodanine heterocycle represents a key structural motif in heterocyclic chemistry and occupies a prominent position in drug discovery. Here, we review some deadly defects of clinical medicines to the therapy of diseases and important advances on rhodanine derivatives in drug researches (e.g. as anti-diabetic, anti-viral, antiinflammatory, anti-microbial, anti-tumor agents and inhibitors for Alzheimer Disease), indicating that rhodanine heterocycle could be used as a significant pharmacophore to develop novel pharmacological active molecules. It is believed that the review is of importance for new ideas in the development of and rational designs of rhodanine-based drugs. Keywords: Adverse effect, bioactivity, drug resistance, rhodanine, pharmacophore, pharmacological active molecule.
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