cccDNA
医学
肝硬化
乙型肝炎病毒
免疫
病毒学
慢性肝炎
丁型肝炎病毒
免疫学
环状DNA
病毒
内科学
免疫系统
生物
乙型肝炎表面抗原
生物化学
基因组
基因
作者
Pierre Tonnerre,Thomas F. Baumert
标识
DOI:10.1016/j.jhep.2024.03.017
摘要
More than 250 million people are infected with hepatitis B virus (HBV) worldwide, despite availability of an effective prophylactic vaccine1,2. Although current standard of care such as nucleos(t)ide analogs (NA) and interferon-alfa (PEG-IFN) are successful in controlling viral replication, these therapies very rarely result in complete cure due to persistence of HBV covalently closed circular DNA (cccDNA) in infected hepatocytes3. Thus, CHB patients remain at high risk of developing cirrhosis and hepatocellular carcinoma2.
科研通智能强力驱动
Strongly Powered by AbleSci AI