Life’s Essential 8 and heart failure among patients with chronic kidney disease: the Kailuan Cohort Study

医学 心力衰竭 危险系数 肾脏疾病 内科学 比例危险模型 置信区间 队列 队列研究 心脏病学 物理疗法
作者
Zhenyu Huo,Zhe Huang,Feng Jun,Junjuan Li,Shuohua Chen,Guodong Wang,Yinshun Peng,Lili Huang,Shouling Wu,Xiang Gao,Yaqi Li,Tingting Geng
出处
期刊:European Journal of Preventive Cardiology [Oxford University Press]
卷期号:31 (7): 824-831 被引量:7
标识
DOI:10.1093/eurjpc/zwad398
摘要

Abstract Aims Patients with chronic kidney disease (CKD) are at an increased risk of developing heart failure. The American Heart Association recently released a new metric, Life’s Essential 8 (LE8), for health promotion. However, evidence regarding associations between LE8 and heart failure risk among patients with CKD is scarce. Methods and results A total of 16 190 patients with CKD (mean age 55.9 years), free of cardiovascular disease at recruitment from the Kailuan Study, were included. Cardiovascular health was assessed using the LE8 score. Incident heart failure events were ascertained via linkage of electronic health record data. Cox proportional hazards regression models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs). There were 814 (5.0%) patients in the high LE8 criteria, with 13 180 (81.4%) in the moderate, and 2196 (13.6%) in the low LE8 category, respectively. During a median follow-up of 13.7 years, 724 incident heart failure cases were documented. Compared with the low LE8 category, the HRs (95% CIs) for heart failure were 0.58 (0.48, 0.71) for the moderate LE8 category and 0.32 (0.19, 0.54) for the high LE8 category (P for trend <0.001). In addition, the association was stronger in patients aged ≤65 years compared with their older counterparts (P for interaction = 0.01). Conclusion Our data showed a strong graded inverse association between the LE8-defined cardiovascular health and the risk of heart failure among patients with CKD. Our findings support the importance of adopting the LE8 among patients with CKD to prevent heart failure.
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