When the missile is flying at high speed, the surface shape and refractive index of the conformal dome will change due to the aero-optic effect, which results in different image quality at different flight times. Hence, it is of great significance to study the influence of flight time on aero-optical imaging quality degradation of the conformal dome. Taking an airto- air missile as an example, this paper uses Zernike polynomials, image simulation, and peak signal-to-noise ratio (PSNR) to evaluate the degeneration of the aero-optical imaging quality of an ellipsoid dome with a flight time range of 0-10 s under varying conditions. The simulation results show that, with the increase of flight time, (1) the dynamic range of tilt, defocus, astigmatism, and coma increase; (2) the PSNRs of the simulated images decrease. Therefore, the effect of flight time on the aero-optic imaging quality degradation of the ellipsoidal dome is gradually serious.