作者
Yuan‐Yuan Cheng,Rong Yang,J. Chen,W. Zhang,Chunguang Xie,Qing Hu,Ningning Zhou,Chun‐Chia Huang,Sheng Wei,Huiying Sun,Xiaofei Li,Yan Yu,Jianbo Lai,Hua Ye,Fang Huang,Hui Chen,Peng-Fei Zhang,Kai Gu,Qi Wang,Jianhua Shi,Tienan Yi,Ximing Xu,X. Ye,Dan Wang,Chunguang Xie,Changxu Liu,Yawen Zheng,Daniel Lin,W. Zhuang,Ping Lu,Guohua Yu,Jun Li,Yue Gu,B. Li,Rong Wu,Ou Jiang,Zhaoguang Wang,Gang Wu,Hao Lin,Diansheng Zhong,Xu Ye,Yongqian Shu,Donghai Wu,Ye Chen,Junye Wang,M. Wang
摘要
Small-cell lung cancer (SCLC) is a recalcitrant malignancy. Despite immunochemotherapy showed promise with a 2-month overall survival (OS) benefits in extensive-stage SCLC (ES-SCLC), improving long-term survival remains an unmet need. Limited benefit might attribute to the complicated SCLC microenvironment, which is characterized by immunosuppression, angiogenesis and vascularization. Tumor microenvironment reprogramming and tumor vessel normalization could promote immune cell infiltration, obtaining synergistic effects with immunotherapy.