化学
环加成
立体中心
硝基
区域选择性
部分
分子内力
芳基
串联
1,3-偶极环加成
催化作用
级联反应
药物化学
组合化学
立体化学
有机化学
对映选择合成
烷基
材料科学
复合材料
作者
Jakub Brześkiewicz,Rafał Loska
标识
DOI:10.1002/adsc.202301113
摘要
Abstract Complex spirocyclic isoindolines and pyrrolidines are formed in a tandem process involving Co(III)‐catalyzed dienylation of cyclic C‐aryl nitrones with 2,3‐butadien‐1‐ol carbonates, followed by intramolecular 1,3‐dipolar cycloaddition. The nitrone moiety serves both as a directing group for the C(aryl)−H activation and the dipole in the cycloaddition step. High regioselectivity of the fused vs. bridged product can be obtained by adjusting the reaction temperature. Reactions with substituted allenic substrates provide heterocycles with additional stereocenters usually with complete diastereoselectivity. The reaction products were readily transformed further into other complex nitrogen‐containing spirocyclic systems.
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