Exploring polysaccharide and protein-enriched decellularized matrix scaffolds for tendon and ligament repair: A review

去细胞化 再生(生物学) 组织工程 脚手架 细胞外基质 再生医学 自愈水凝胶 生物医学工程 细胞生物学 材料科学 生物 干细胞 医学 高分子化学
作者
Shabnam Anjum,Ting Li,Mohammad Saeed,Qiang Ao
出处
期刊:International Journal of Biological Macromolecules [Elsevier BV]
卷期号:254: 127891-127891 被引量:7
标识
DOI:10.1016/j.ijbiomac.2023.127891
摘要

Tissue engineering (TE) has become a primary research topic for the treatment of diseased or damaged tendon/ligament (T/L) tissue. T/L injuries pose a severe clinical burden worldwide, necessitating the development of effective strategies for T/L repair and tissue regeneration. TE has emerged as a promising strategy for restoring T/L function using decellularized extracellular matrix (dECM)-based scaffolds. dECM scaffolds have gained significant prominence because of their native structure, relatively high bioactivity, low immunogenicity, and ability to function as scaffolds for cell attachment, proliferation, and differentiation, which are difficult to imitate using synthetic materials. Here, we review the recent advances and possible future prospects for the advancement of dECM scaffolds for T/L tissue regeneration. We focus on crucial scaffold properties and functions, as well as various engineering strategies employed for biomaterial design in T/L regeneration. dECM provides both the physical and mechanical microenvironments required by cells to survive and proliferate. Various decellularization methods and sources of allogeneic and xenogeneic dECM in T/L repair and regeneration are critically discussed. Additionally, dECM hydrogels, bio-inks in 3D bioprinting, and nanofibers are briefly explored. Understanding the opportunities and challenges associated with dECM-based scaffold development is crucial for advancing T/L repairs in tissue engineering and regenerative medicine.
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