间质细胞
肿瘤微环境
免疫系统
生物
卵巢癌
细胞代谢
转移
癌细胞
细胞外基质
癌症研究
微泡
癌症
趋化因子
肿瘤进展
细胞
细胞生物学
免疫学
小RNA
生物化学
遗传学
基因
作者
Priscilla W. Tang,Leonard Frisbie,Nadine Hempel,Lan Coffman
出处
期刊:American Journal of Physiology-cell Physiology
[American Physical Society]
日期:2023-09-01
卷期号:325 (3): C731-C749
被引量:2
标识
DOI:10.1152/ajpcell.00588.2022
摘要
The ovarian cancer tumor microenvironment (TME) consists of a constellation of abundant cellular components, extracellular matrix, and soluble factors. Soluble factors, such as cytokines, chemokines, structural proteins, extracellular vesicles, and metabolites, are critical means of noncontact cellular communication acting as messengers to convey pro- or antitumorigenic signals. Vast advancements have been made in our understanding of how cancer cells adapt their metabolism to meet environmental demands and utilize these adaptations to promote survival, metastasis, and therapeutic resistance. The stromal TME contribution to this metabolic rewiring has been relatively underexplored, particularly in ovarian cancer. Thus, metabolic activity alterations in the TME hold promise for further study and potential therapeutic exploitation. In this review, we focus on the cellular components of the TME with emphasis on 1) metabolic signatures of ovarian cancer; 2) understanding the stromal cell network and their metabolic cross talk with tumor cells; and 3) how stromal and tumor cell metabolites alter intratumoral immune cell metabolism and function. Together, these elements provide insight into the metabolic influence of the TME and emphasize the importance of understanding how metabolic performance drives cancer progression.
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