医学
全国死亡指数
全国健康与营养检查调查
2型糖尿病
糖化血红素
置信区间
糖尿病
人口学
队列
死亡风险
癌症
队列研究
内科学
死亡率
死因
环境卫生
人口
疾病
危险系数
内分泌学
社会学
作者
Dikang Pan,Jiahuan Guo,Zhixiang Su,Jingyu Wang,Sensen Wu,Jianming Guo,Yongquan Gu
标识
DOI:10.1186/s13098-023-01138-2
摘要
There are studies on the nutritional status of type 2 diabetes (T2D), but there are no large cohort studies on the prognosis of Controlling Nutritional Status (CONUT) score for T2D. The aim of this study was to examine the association between CONUT score and all-cause mortality as well as cancer mortality in adults with T2D.For this study, we analyzed a total of 3763 adult patients with T2D who were part of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. Mortality outcomes were determined by linking to the National Death Index records as of December 31, 2019. Cox proportional risk models were used to estimate risk ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cancer deaths.During the mean follow-up of 8.17 years, there were 823 deaths from all causes and 155 deaths from cancer. After adjusting for multiple variables, the risk of all-cause mortality was higher in patients with a Mild (CONUT score ≥ 2), compared with patients with a Normal (CONUT score of 0-1). All-cause mortality risk was 39% higher, and cancer mortality risk was 45% higher. Consistent results were observed when stratified by age, sex, race, BMI, smoking status, and glycated hemoglobin levels.In a nationally representative sample of American adults with T2D, we found an association between CONUT score and all-cause mortality and cancer mortality.
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