Preoperative endoscopic biliary drainage by metal versus plastic stents for resectable perihilar cholangiocarcinoma

Background and study aims:Adequate preoperative biliary drainage (PBD) is recommended in most patients with resectable perihilar cholangiocarcinoma (pCCA).Most expert centers use endoscopic plastic stents rather than selfexpanding metal stents (SEMS).In the palliative setting, however, use of SEMS has shown longer patency and superior survival.The aim of this retrospective study was to compare stent dysfunction of SEMS versus plastic stents for PBD in resectable pCCA patients. Patients and methods:In this retrospective, multicenter, international cohort study, patients with a potentially resectable pCCA who underwent initial endoscopic PBD were included from 2010-2020.Stent failure was a composite endpoint of cholangitis and/or re-intervention due to adverse events or insufficient PBD.Other adverse events, surgical outcomes, and survival were recorded.Propensity score matching (PSM) was performed on several baseline characteristics. Results:474 patients had successful stent placement, of whom 61 received SEMS and 413 plastic stents.PSM (1:1) resulted in two groups of 59 patients.Stent failure occurred significantly less in the SEMS group (31% vs 64%, p<0.001).Besides less cholangitis after SEMS placement (15% vs 31%, p = 0.012), other PBD-related adverse events did not differ.The number of patients undergoing surgical resection was not significantly different (46% vs 49%, p = 0.71).Complete intraoperative SEMS removal was successful and without adverse events in all patients.J o u r n a l P r e -p r o o f 5 Conclusions:Stent failure was lower in patients with SEMS as PBD compared to plastic stents in patients with resectable pCCA.Removal during surgery was well feasible.Surgical outcomes were comparable.