吞噬作用
自噬
发病机制
炎症
生物
疾病
免疫学
医学
病理
细胞凋亡
遗传学
作者
Xu Chen,Qi Su,Rui-Ze Gong,Xing Ling,Runxiao Xu,Qijia Feng,J Ke,Meng Liu,Gulipiyanmu Kahaerjiang,Y.C. Liu,Yanyan Yang,Zhi‐Hong Jiang,Hongmei Wu,Yitao Qi
标识
DOI:10.1096/fj.202402126r
摘要
Abstract LC3‐associated phagocytosis (LAP) is a distinct type of autophagy that involves the sequestration of extracellular material by phagocytes. Beyond the removal of dead cells and cellular debris from eukaryotic cells, LAP is also involved in the removal of a variety of pathogens, including bacteria, fungi, and viruses. These events are integral to multiple physiological and pathological processes, such as host defense, inflammation, and tissue homeostasis. Dysregulation of LAP has been associated with the pathogenesis of several human diseases, including infectious diseases, autoimmune diseases, and neurodegenerative diseases. Thus, understanding the molecular mechanisms underlying LAP and its involvement in human diseases may provide new insights into the development of novel therapeutic strategies for these conditions. In this review, we summarize and highlight the current consensus on the role of LAP and its biological functions in disease progression to propose new therapeutic strategies. Further studies are needed to illustrate the precise role of LAP in human disease and to determine new therapeutic targets for LAP‐associated pathologies.
科研通智能强力驱动
Strongly Powered by AbleSci AI