Automated detection of large vessel occlusion using deep learning: a pivotal multicenter study and reader performance study

医学 接收机工作特性 置信区间 冲程(发动机) 闭塞 多中心研究 放射科 内科学 随机对照试验 机械工程 工程类
作者
Jae Guk Kim,Sue Young Ha,You-Ri Kang,Hotak Hong,Dongmin Kim,Myung-Jae Lee,Leonard Sunwoo,Wi‐Sun Ryu,Joon‐Tae Kim
出处
期刊:Journal of NeuroInterventional Surgery [BMJ]
卷期号:: jnis-022254 被引量:1
标识
DOI:10.1136/jnis-2024-022254
摘要

Background To evaluate the stand-alone efficacy and improvements in diagnostic accuracy of early-career physicians of the artificial intelligence (AI) software to detect large vessel occlusion (LVO) in CT angiography (CTA). Methods This multicenter study included 595 ischemic stroke patients from January 2021 to September 2023. Standard references and LVO locations were determined by consensus among three experts. The efficacy of the AI software was benchmarked against standard references, and its impact on the diagnostic accuracy of four residents involved in stroke care was assessed. The area under the receiver operating characteristic curve (AUROC), sensitivity, and specificity of the software and readers with versus without AI assistance were calculated. Results Among the 595 patients (mean age 68.5±13.4 years, 56% male), 275 (46.2%) had LVO. The median time interval from the last known well time to the CTA was 46.0 hours (IQR 11.8–64.4). For LVO detection, the software demonstrated a sensitivity of 0.858 (95% CI 0.811 to 0.897) and a specificity of 0.969 (95% CI 0.943 to 0.985). In subjects whose symptom onset to imaging was within 24 hours (n=195), the software exhibited an AUROC of 0.973 (95% CI 0.939 to 0.991), a sensitivity of 0.890 (95% CI 0.817 to 0.936), and a specificity of 0.965 (95% CI 0.902 to 0.991). Reading with AI assistance improved sensitivity by 4.0% (2.17 to 5.84%) and AUROC by 0.024 (0.015 to 0.033) (all P<0.001) compared with readings without AI assistance. Conclusions The AI software demonstrated a high detection rate for LVO. In addition, the software improved diagnostic accuracy of early-career physicians in detecting LVO, streamlining stroke workflow in the emergency room.
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