可穿戴计算机
等离子体子
纳米技术
可穿戴技术
汗水
材料科学
化学
光电子学
计算机科学
嵌入式系统
医学
内科学
作者
Guoqun Li,Xing Zhao,Xiao Tang,Lei Yao,Weiyi Li,Jiawei Wang,Xiaojing Liu,Bing Han,Xingce Fan,Teng Qiu,Qi Hao
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-10-11
标识
DOI:10.1021/acs.nanolett.4c04267
摘要
Uric acid is typically measured through blood tests, which can be inconvenient and uncomfortable for patients. Herein, we propose a wearable surface-enhanced Raman scattering (SERS) chip, incorporating a hydrogel membrane with integrated plasmonic trimers, for noninvasive monitoring of uric acid in sweat. The plasmonic trimers feature sub 5 nm nanogaps, generating strong electromagnetic fields to boost the Raman signal of surrounding molecules. Simultaneously, the hydrogel membrane pumps sweat through these gaps, efficiently capturing sweat biomarkers for SERS detection. The chip can achieve saturation adsorption of sweat within 5 min, eliminating variations in individual sweat production rates. Dynamic SERS tracking of uric acid and lactic acid levels during anaerobic exercise reveals a temporary suppression of uric acid metabolism, likely due to metabolic competition with lactic acid. Furthermore, long-term monitoring correlates well with blood test results, confirming that regular exercise helps reduce serum uric acid levels and supporting its potential in managing hyperuricemia.
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