Hybrid Zinc Oxide Nanocoating on Titanium Implants: Controlled Drug Release for Enhanced Antibacterial and Osteogenic Performance in Infectious Conditions

材料科学 药品 生物医学工程 生物相容性 纳米技术 药理学 冶金 医学
作者
Juncen Zhou,Hanbo Wang,Sannakaisa Virtanen,Lukasz Witek,Hongzhou Dong,David G. Thanassi,Youqing Shen,Yunzhi Yang,Cunjiang Yu,Donghui Zhu
出处
期刊:Acta Biomaterialia [Elsevier]
标识
DOI:10.1016/j.actbio.2024.09.039
摘要

Implant-associated bacterial infections are a primary cause of complications in orthopedic implants, and localized drug delivery represents an effective mitigation strategy. Drawing inspiration from the morphology of desiccated soil, our group has developed an advanced drug-delivery system augmented onto titanium (Ti) plates. This system integrates zinc oxide (ZnO) nanorod arrays with a vancomycin drug layer along with a protective Poly(lactic-co-glycolic acid) (PLGA) coating. The binding between the ZnO nanorods and the drug results in attached drug blocks, isolated by desiccation-like cracks, which are then encapsulated by PLGA to enable sustained drug release. Additionally, the release of zinc ions and the generation of reactive oxygen species (ROS) from the ZnO nanorods enhance the antibacterial efficacy. The antibacterial properties of ZnO nanorod-drug-PLGA system have been validated through both in vitro and in vivo studies. Comprehensive investigations were conducted on the impact of bacterial infections on bone defect regeneration and the role of this drug-delivery system in the healing process. Furthermore, the local immune response was analyzed and the immunomodulatory function of the system was demonstrated. Overall, the findings underscore the superior performance of the ZnO nanorod-drug-PLGA system as an efficient and safe approach to combat implant-associated bacterial infections. STATEMENT OF SIGNIFICANCE: Implant-associated bacterial infections pose a significant clinical challenge, particularly in orthopedic procedures. To address this, we developed an innovative ZnO nanorod-drug-PLGA system for local antibiotic delivery on conventional titanium implants. This system is biodegradable and features a unique desiccation-like structure that enables sustained drug release, along with the active substances released from the ZnO nanorods. In a rat calvarial defect model challenged with S. aureus, our system demonstrated remarkable antibacterial efficacy, significantly enhanced bone defect regeneration, and exhibited local immunomodulatory effects that support both infection control and osteogenesis. These breakthrough findings highlight the substantial clinical potential of this novel drug delivery system and introduce a transformative coating strategy to enhance the functionality of traditional metallic biomaterials.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
月亮打盹儿完成签到 ,获得积分10
刚刚
chuanfu完成签到,获得积分10
刚刚
刚刚
ccc完成签到,获得积分10
1秒前
血小板发布了新的文献求助10
1秒前
laika完成签到,获得积分10
1秒前
1秒前
1秒前
木偶完成签到 ,获得积分10
2秒前
Air云完成签到,获得积分10
2秒前
3秒前
随机昵称完成签到,获得积分10
4秒前
大个应助gaga8采纳,获得10
4秒前
Dr.L完成签到,获得积分10
5秒前
6秒前
6秒前
842413119完成签到,获得积分10
6秒前
zhelm发布了新的文献求助10
6秒前
无忧应助没问题采纳,获得10
6秒前
潇洒映冬发布了新的文献求助10
6秒前
优雅的纸鹤完成签到,获得积分10
7秒前
蜗牛完成签到,获得积分10
7秒前
7秒前
7秒前
欢喜蛋挞完成签到,获得积分10
7秒前
惊鸿客应助luca采纳,获得30
9秒前
白方明完成签到,获得积分10
9秒前
10秒前
动听平露完成签到,获得积分10
10秒前
yun尘世完成签到,获得积分10
10秒前
mochou完成签到,获得积分20
12秒前
Gg121380发布了新的文献求助10
13秒前
Battery-Li完成签到,获得积分10
13秒前
迷路的游侠完成签到,获得积分10
13秒前
14秒前
woollen2022完成签到,获得积分10
14秒前
奋斗的桐完成签到 ,获得积分10
15秒前
xxxxxxxx完成签到 ,获得积分10
15秒前
会飞的胖子完成签到,获得积分20
15秒前
RSC完成签到,获得积分10
16秒前
高分求助中
Sustainability in Tides Chemistry 1500
Handbook of the Mammals of the World – Volume 3: Primates 805
Ethnicities: Media, Health, and Coping 800
Gerard de Lairesse : an artist between stage and studio 500
Digging and Dealing in Eighteenth-Century Rome 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Manual of Sewer Condition Classification 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3068941
求助须知:如何正确求助?哪些是违规求助? 2722771
关于积分的说明 7479022
捐赠科研通 2369730
什么是DOI,文献DOI怎么找? 1256623
科研通“疑难数据库(出版商)”最低求助积分说明 609614
版权声明 596839