High fibrin and platelet clot predicts stroke recurrence or mortality after thrombectomy in patients with active cancer

医学 冲程(发动机) 癌症 内科学 血栓 优势比 队列 血栓形成 外科 胃肠病学 机械工程 工程类
作者
Chuan-Hsiu Fu,Chih‐Hao Chen,Yen‐Heng Lin,Chung‐Wei Lee,Li‐Kai Tsai,Sung‐Chun Tang,Chia‐Tung Shun,Jiann‐Shing Jeng
出处
期刊:Journal of NeuroInterventional Surgery [BMJ]
卷期号:: jnis-022033 被引量:2
标识
DOI:10.1136/jnis-2024-022033
摘要

Background Fibrin and platelet (FP)-rich clots have been shown to be associated with cancer-related stroke. This study aims to investigate the prognostic role of thrombus composition in clinical outcomes among cancer patients who experienced stroke and received endovascular thrombectomy (EVT). Methods We included acute ischemic stroke patients who underwent EVT between March 2015 and November 2021. These patients were categorized into three groups: those with active cancer, those with non-active cancer, and those without cancer. The percentages of FP in clots were quantified under hematoxylin and eosin staining. The primary outcome was defined as any stroke recurrence or mortality within 90 days following the index stroke event. Results A total of 420 patients with retrieved clots were included in the study. This cohort comprised 50 patients with active cancer, 23 patients with non-active cancer, and 347 patients without cancer. The percentage of FP was significantly higher in thrombi retrieved from patients with active cancer compared with the other two groups. Patients in the active cancer group exhibited a higher rate of the primary outcome compared with the other groups. After adjusting for clinical variables, a higher percentage of FP in thrombi remained significantly associated with the primary outcome in the active cancer group (adjusted odds ratio (aOR) =1.03 (1.00–1.06), P=0.028), but not in the other two groups. Conclusion Among stroke patients receiving EVT, thrombi with a higher percentage of FP not only identify individuals with active cancer but also predict stroke recurrence or mortality within 90 days.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
谷歌完成签到,获得积分10
1秒前
顺利的语山完成签到,获得积分20
1秒前
871624521完成签到,获得积分10
1秒前
隐形曼青应助苗苗043采纳,获得10
1秒前
Cmax_关注了科研通微信公众号
1秒前
chen完成签到,获得积分10
2秒前
2秒前
务实的紫伊完成签到,获得积分10
2秒前
zwy1216完成签到,获得积分10
2秒前
didi完成签到,获得积分10
3秒前
zzy加油发布了新的文献求助10
3秒前
李保龙完成签到 ,获得积分10
3秒前
Crazykk完成签到,获得积分10
4秒前
guoguo发布了新的文献求助30
4秒前
4秒前
顾矜应助白茶采纳,获得10
4秒前
张美玲发布了新的文献求助10
5秒前
Hello应助shiyaouao采纳,获得10
5秒前
鱼香肉丝完成签到,获得积分10
5秒前
fy207发布了新的文献求助10
6秒前
wsy完成签到,获得积分10
6秒前
领导范儿应助lele7458采纳,获得10
7秒前
研友_LX0JxL发布了新的文献求助30
8秒前
小学渣完成签到,获得积分10
9秒前
蓝天阳光完成签到,获得积分10
10秒前
子虞完成签到,获得积分10
10秒前
wy.he应助MrPao采纳,获得10
10秒前
11秒前
时光完成签到,获得积分10
11秒前
英姑应助满意芯采纳,获得10
11秒前
飞云发布了新的文献求助10
12秒前
负责的谷槐完成签到,获得积分20
12秒前
zzz关闭了zzz文献求助
12秒前
沐沐完成签到 ,获得积分20
13秒前
summer完成签到,获得积分10
16秒前
16秒前
16秒前
王哥完成签到,获得积分10
16秒前
fy207完成签到,获得积分10
16秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969033
求助须知:如何正确求助?哪些是违规求助? 3513900
关于积分的说明 11170818
捐赠科研通 3249256
什么是DOI,文献DOI怎么找? 1794708
邀请新用户注册赠送积分活动 875326
科研通“疑难数据库(出版商)”最低求助积分说明 804759