Evidence that robot-assisted gait training modulates neuroplasticity after stroke: An fMRI pilot study based on graph theory analysis

步态训练 冲程(发动机) 物理医学与康复 神经可塑性 康复 心理学 磁共振成像 功能磁共振成像 医学 物理疗法 内科学 神经科学 放射科 机械工程 工程类
作者
Zhiqing Tang,Yaxian Zhao,Xinting Sun,Ying Liu,Wenlong Su,Tianhao Liu,Xiaonian Zhang,Hao Zhang
出处
期刊:Brain Research [Elsevier BV]
卷期号:1842: 149113-149113
标识
DOI:10.1016/j.brainres.2024.149113
摘要

To investigate alterations of whole-brain network after stroke and therapeutic mechanisms of robot-assisted gait training (RAGT). 21 S patients and 20 healthy subjects were enrolled, with the stroke patients randomized to either control group (n = 11) or robot group (n = 10), and resting-state functional magnetic resonance imaging data were collected. The global network metrics were obtained using graph theory analysis and compared between stroke patients and healthy subjects, and the effect of the RAGT on the whole-brain networks was explored. Compared to healthy subjects, area under the curve (AUC) for small-worldness (σ), clustering coefficient (Cp), global efficiency (Eg) and mean local efficiency (Eloc) were significantly lower in stroke patients, whereas AUC for characteristic path length (Lp) were significantly higher. Compared with the control group, patients in robot group showed significant improvement in lower limb motor function, balance function and walking function after intervention, with a significant reduction in the AUC of Cp. Moreover, the improvement of walking function was positively correlated with the changes of AUC of σ and Eg, and negatively correlated with the changes of AUC of Cp. Small-worldness and network efficiency were significantly reduced after stroke, whereas RAGT decreased characteristic path length and promoted normalization of the whole-brain network, and this change was associated with improvement in walking function. Our findings reveal the mechanism by which RAGT regulates network reorganization and neuroplasticity after stroke.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
白桦林泪发布了新的文献求助10
1秒前
正直莫英发布了新的文献求助10
2秒前
3秒前
4秒前
HLQF完成签到,获得积分10
5秒前
江边鸟完成签到 ,获得积分10
6秒前
hg08完成签到,获得积分10
7秒前
丘比特应助小药同学采纳,获得10
7秒前
烟花应助zz采纳,获得10
9秒前
10秒前
卡卡罗特发布了新的文献求助10
11秒前
正直莫英完成签到,获得积分10
12秒前
黄彤彤关注了科研通微信公众号
12秒前
丁仪发布了新的文献求助10
12秒前
852应助毛毛采纳,获得10
12秒前
xyjf15完成签到,获得积分10
12秒前
卡尔拉完成签到,获得积分10
12秒前
Jasper应助Xylah_Rebecca采纳,获得10
15秒前
15秒前
SYLH应助赵杰采纳,获得10
15秒前
孙燕应助白桦林泪采纳,获得30
16秒前
田様应助白桦林泪采纳,获得10
16秒前
义气冷菱发布了新的文献求助10
16秒前
慕青应助Eleanor采纳,获得10
16秒前
17秒前
kitty完成签到 ,获得积分10
18秒前
李健的粉丝团团长应助Gao采纳,获得10
18秒前
要减肥完成签到,获得积分20
20秒前
21秒前
嘞是举仔发布了新的文献求助10
22秒前
黄彤彤发布了新的文献求助30
27秒前
顾矜应助hanshu采纳,获得10
27秒前
29秒前
30秒前
w1完成签到,获得积分10
30秒前
田様应助沐晴采纳,获得10
31秒前
丘比特应助嘞是举仔采纳,获得10
31秒前
31秒前
温暖的沛凝完成签到 ,获得积分10
32秒前
automan完成签到,获得积分10
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989797
求助须知:如何正确求助?哪些是违规求助? 3531910
关于积分的说明 11255394
捐赠科研通 3270563
什么是DOI,文献DOI怎么找? 1805008
邀请新用户注册赠送积分活动 882157
科研通“疑难数据库(出版商)”最低求助积分说明 809190