神经科学
帕金森病
疾病
医学
心理学
运动皮层
物理医学与康复
病理
刺激
作者
Hong‐Yuan Chu,Yoland Smith,William W. Lytton,Scott T. Grafton,Rosa M. Villalba,Gunasingh Masilamoni,Thomas Wichmann
出处
期刊:Cerebral Cortex
[Oxford University Press]
日期:2024-07-01
卷期号:34 (7)
被引量:2
标识
DOI:10.1093/cercor/bhae294
摘要
Abstract The cerebral cortex has long been thought to be involved in the pathophysiology of motor symptoms of Parkinson’s disease. The impaired cortical function is believed to be a direct and immediate effect of pathologically patterned basal ganglia output, mediated to the cerebral cortex by way of the ventral motor thalamus. However, recent studies in humans with Parkinson’s disease and in animal models of the disease have provided strong evidence suggesting that the involvement of the cerebral cortex is much broader than merely serving as a passive conduit for subcortical disturbances. In the present review, we discuss Parkinson’s disease–related changes in frontal cortical motor regions, focusing on neuropathology, plasticity, changes in neurotransmission, and altered network interactions. We will also examine recent studies exploring the cortical circuits as potential targets for neuromodulation to treat Parkinson’s disease.
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