外体
免疫疗法
癌症免疫疗法
医学
免疫原性
微泡
癌症
癌症疫苗
癌症研究
免疫学
免疫系统
内科学
生物
小RNA
生物化学
基因
作者
Jiarong Ye,Danni Li,Yiting Jie,Hongliang Luo,Wenjun Zhang,Cheng Qiu
标识
DOI:10.1016/j.biopha.2024.117296
摘要
Over the past decades, cancer immunotherapy has encountered challenges such as immunogenicity, inefficiency, and cytotoxicity. Consequently, exosome-based cancer immunotherapy has gained rapid traction as a promising alternative. Exosomes, a type of extracellular vesicles (EVs) ranging from 50 to 150 nm, are self-originating and exhibit fewer side effects compared to traditional therapies. Exosome-based immunotherapy encompasses three significant areas: cancer vaccination, co-inhibitory checkpoints, and adoptive T-cell therapy. Each of these fields leverages the inherent advantages of exosomes, demonstrating substantial potential for individualized tumor therapy and precision medicine. This review aims to elucidate the reasons behind the promise of exosome-based nanoparticles as cancer therapies by examining their characteristics and summarizing the latest research advancements in cancer immunotherapy.
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