神经保护
视网膜
缺血
糖尿病性视网膜病变
视网膜
自愈水凝胶
再灌注损伤
药理学
医学
青光眼
外体
视网膜中央动脉阻塞
视神经
细胞凋亡
视网膜神经节细胞
微泡
眼科
化学
小RNA
神经科学
生物
糖尿病
生物化学
内科学
内分泌学
基因
有机化学
作者
Mengling You,Rong Rong,Zhuotao Liang,Sijian Xie,Xiaoya Ma,Xiaobo Xia
标识
DOI:10.1016/j.cej.2024.154509
摘要
Retinal ischemia–reperfusion is a major cause of vision loss in a variety of ocular diseases, including glaucoma, age-related macular degeneration, diabetic retinopathy, and central retinal artery occlusion. Previous studies have reported the protective effects of injectable hydrogels in optic nerve injury, but reports of multifunctional hydrogels loaded with drugs and bioactive substances that synergistically promote neuroprotection are rare. Here, we designed an injectable, drug-loaded, and reactive oxygen species responsive multifunctional hydrogel. Upon intravitreal injection into a retinal ischemia–reperfusion injury model in mice, the hydrogel released exosomes and liproxstatin-1 over an extended period exceeding a month, leading to a significant recovery of visual function and reduction of retinal ganglion cell loss. The effect was superior to that of the common drug and exosome combination. The results of this study suggest that this multifunctional hydrogel is expected to advance retinal tissue engineering and provide an innovative strategy for acute neuroprotection in retinal ischemia–reperfusion injury.
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