DNA Methylation Age Mediates Effect of Metabolic Profile on Cardiovascular and General Aging

DNA甲基化甲基化衰老生物表观遗传学 DNA 遗传学内分泌学医学内科学细胞生物学生物信息学生理学基因基因表达

作者

Jiahui Si,Yu Ma,Canqing Yu,Dianjianyi Sun,Yuanjie Pang,Pei Pei,Ling Yang,Iona Y. Millwood,Robin Walters,Yiping Chen,Huaidong Du,Xiaoyan Zheng,Daniel Avery,Junshi Chen,Zhengming Chen,Liming Liang,Liming Li,Jun Lv,Rory Collins,Richard Peto,Ruth Boxall,Derrick Bennett,Yu‐Mei Chang,Robert Clarke,Simon Gilbert,Alex Hacker,Michael V. Holmes,Andri Iona,Christiana Kartsonaki,Rene Kerosi,Ling Kong,Om Kurmi,Garry Lancaster,Sarah Lewington,Kuang Lin,John McDonnell,Xue W. Mei,Qunhua Nie,Jayakrishnan Radhakrishnan,Sajjad Rafiq,Paul Ryder,Sam Sansome,Dan Schmidt,Paul Sherliker,Rajani Sohoni,Iain Turnbull,Jenny Wang,Lin Wang,Xiaoming Yang,Zheng Bian,Ge Chen,Yu Guo,Can Hou,LV Jun,Shuzhen Qu,Yunlong Tan,Canqing Yu,Zengchang Pang,Ruqin Gao,Shaojie Wang,Yongmei Liu,Huaidong Du,Yajing Zang,Cheng Liang,Xiaocao Tian,Hua Zhang,Jun Lv,Junzheng Wang,Wei Hou,Jiyuan Yin,Ge Jiang,Xue Zhou,Liqiu Yang,Hui He,Bo Yu,Yanjie Li,Huaiyi Mu,Qinai Xu,Meiling Dou,Jiaojiao Ren,Shanqing Wang,Ximin Hu,Hongmei Wang,Jinyan Chen,Yan Fu,Zhenwang Fu,Xiaohuan Wang,Min Weng,Xiangyang Zheng,Yilei Li,Huimei Li,Yanjun Wang,Ming Wu,Jinyi Zhou,Ran Tao,Jie Yang,Chuanming Ni,Jun Zhang,Yihe Hu,Yan Lü,Wei Ma,Aiyu Tang,Shuo Zhang,Jianrong Jin,Jingchao Liu,Zhenzhu Tang,Naying Chen,Ying Huang,Mingqiang Li,Jinhuai Meng,Rong Pan,Qilian Jiang,Weiyuan Zhang,Yun Liu,Liuping Wei,Liyuan Zhou,Ningyu Chen,Hairong Guan,Xianping Wu,Ningmei Zhang,Xiaofang Chen,Xuefeng Tang,Guojin Luo,Jianguo Li,Xiaofang Chen,Xunfu Zhong,Jiaqiu Liu,Qiang Sun,Pengfei Ge,Xiaolan Ren,Caixia Dong,Hui Zhang,Enke Mao,Xiaoping Wang,Tao Wang,Xi Zhang,Ding Zhang,Gang Zhou,Shixian Feng,Liang Chang,Lei Fan,Yulian Gao,Tianyou He,Huarong Sun,Pan He,Hu Chen,Qiannan Lv,Xukui Zhang,Yu Min,Ruying Hu,Hao Wang,Yijian Qian,Chunmei Wang,Kaixue Xie,Lingli Chen,Yidan Zhang,Dongxia Pan,Yuelong Huang,Biyun Chen,Yin Li,Donghui Jin,Huilin Liu,Zhongxi Fu,Qiaohua Xu,Xin Xu,Hao Zhang,Youping Xiong,Huajun Long,Xianzhi Li,Libo Zhang,Zhe Qiu

出处

期刊：Circulation Research [Ovid Technologies (Wolters Kluwer)]
日期：2024-09-23

链接

nih.govdoi.org

标识

DOI：10.1161/circresaha.124.325066

摘要

Alterations in lipid metabolism and DNA methylation are 2 hallmarks of aging. Connecting metabolomic, epigenomic, and aging outcomes help unravel the complex mechanisms underlying aging. We aimed to assess whether DNA methylation clocks mediate the association of circulating metabolites with incident atherosclerotic cardiovascular disease (ASCVD) and frailty.

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DNA Methylation Age Mediates Effect of Metabolic Profile on Cardiovascular and General Aging

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