先天免疫系统
吞噬作用
免疫系统
巨噬细胞
金黄色葡萄球菌
过继性细胞移植
微生物学
肺炎
免疫学
生物
医学
T细胞
细菌
内科学
体外
生物化学
遗传学
作者
Xiaoyi Liu,Wenxiu Xu,Junkun Feng,Ying Wang,Kai Li,Yi Chen,Wenjun Wang,Weiwei Zhao,Shaohua Ge,Jianhua Li
标识
DOI:10.1038/s41467-025-56460-2
摘要
Bacterial infections pose a significant threat to human health. Catalytic antibacterial nanoparticles that generate reactive oxygen species (ROS) are emerging, as a promising therapeutic approach in treating bacterial infection by boosting the innate immune defenses. However, the interaction between innate immune cells and these catalytic nanoparticles remains poorly understood. Here, by using rodent models of bacterial infection, we test the antimicrobial properties of ultrasound-responsive piezo-catalytic nanoparticles (piezoNP). We show that piezoNPs strongly interact with macrophages within subcutaneous abscesses caused by Staphylococcus aureus (S. aureus) infections, and demonstrate that this interaction enhances the macrophage-mediated antibacterial phagocytosis and killing activity through intracellular piezocatalysis. Moreover, we test the use of these piezo-activated macrophages (piezoMϕ) as adoptive cell therapy (ACT) for treating various immunosuppressive bacterial infections, including sepsis, pneumonia and peritonitis. Our study thus highlights the potential application of catalytic nanoparticles as a promising alternative to conventional infection treatment to effectively modulate the innate immune responses and to engineer macrophages for immunotherapy purposes.
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