化学
对映选择合成
钯
赫克反应
组合化学
铃木反应
催化作用
联轴节(管道)
有机化学
机械工程
工程类
作者
Lei Wang,Wenyu Zhang,Shuaijie Wu,Qing Wu,Ying Han,Chao‐Guo Yan,Guodong Zhang
标识
DOI:10.1021/acs.orglett.4c04239
摘要
We present a tandem aza-Heck/Suzuki cross-coupling reaction of O-phenyl hydroxamic ethers with readily available arylboronic and alkenyl boronic acids. This protocol is enabled by a palladium catalyst paired with chiral phosphoramidite ligands, particularly under mild reaction conditions, yielding efficient and succinct synthetic routes to chiral isoindolinones with high enantioselectivity. Furthermore, this reaction exhibits excellent functional group compatibility and a rich diversity of subsequent transformations.
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