Building resilience and reversing frailty: a randomised controlled trial of a primary care intervention for older adults

医学 物理疗法 随机对照试验 握力 置信区间 心理干预 干预(咨询) 生物电阻抗分析 优势比 老年学 体质指数 内科学 护理部
作者
John Travers,Román Romero‐Ortuño,John Langan,Fergal MacNamara,Darren McCormack,Christopher McDermott,Jude McEntire,Joanne McKiernan,Seán Lacey,Peter Doran,Dermot Power,Marie Therese Cooney
出处
期刊:Age and Ageing [Oxford University Press]
卷期号:52 (2) 被引量:26
标识
DOI:10.1093/ageing/afad012
摘要

Abstract Background There is a need for effective primary care interventions that help older people combat frailty and build resilience. Objective To study the effectiveness of an optimised exercise and dietary protein intervention. Design Multicentre, randomised-controlled, parallel-arm trial. Setting Six primary care practices, Ireland. Methods Six general practitioners enrolled adults aged 65+ with Clinical Frailty Scale score ≤5 from December 2020 to May 2021. Participants were randomised to intervention or usual care with allocation concealed until enrolment. Intervention comprised a 3-month home-based exercise regime, emphasising strength, and dietary protein guidance (1.2 g/kg/day). Effectiveness was measured by comparing frailty levels, based on the SHARE-Frailty Instrument, on an intention-to-treat basis. Secondary outcomes included bone mass, muscle mass and biological age measured by bioelectrical impedance analysis. Ease of intervention and perceived health benefit were measured on Likert scales. Results Of the 359 adults screened, 197 were eligible and 168 enrolled; 156 (92.9%) attended follow-up (mean age 77.1; 67.3% women; 79 intervention, 77 control). At baseline, 17.7% of intervention and 16.9% of control participants were frail by SHARE-FI. At follow-up, 6.3 and 18.2% were frail, respectively. The odds ratio of being frail between intervention and control groups post-intervention was 0.23 (95% confidence interval: 0.07–0.72; P = 0.011), adjusting for age, gender and site. Absolute risk reduction was 11.9% (CI: 0.8%–22.9%). Number needed to treat was 8.4. Grip strength (P < 0.001) and bone mass (P = 0.040) improved significantly. 66.2% found the intervention easy, 69.0% reported feeling better. Conclusion A combination of exercises and dietary protein significantly reduced frailty and improved self-reported health.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Yasong发布了新的文献求助10
刚刚
pompous完成签到 ,获得积分10
刚刚
量子星尘发布了新的文献求助100
1秒前
天天快乐应助tao采纳,获得10
1秒前
可爱的函函应助论文多多采纳,获得10
1秒前
2秒前
2秒前
2秒前
我心匪石不可转完成签到,获得积分10
2秒前
玩命的青亦完成签到,获得积分10
2秒前
YamDaamCaa应助叫秋田犬的猫采纳,获得30
2秒前
sunly发布了新的文献求助10
3秒前
112255发布了新的文献求助30
3秒前
彭于晏应助zycdx3906采纳,获得10
3秒前
3秒前
4秒前
4秒前
千跃应助刘钱美子采纳,获得20
5秒前
星辰大海应助yueyueyue采纳,获得10
5秒前
大模型应助共情采纳,获得10
6秒前
baiweizi发布了新的文献求助10
6秒前
发财小鱼完成签到 ,获得积分10
6秒前
7秒前
Wen发布了新的文献求助10
7秒前
7秒前
8秒前
8秒前
illuminate完成签到 ,获得积分10
8秒前
8秒前
李永畅完成签到,获得积分10
8秒前
8秒前
莫西莫西发布了新的文献求助10
9秒前
9秒前
蓝刺发布了新的文献求助10
9秒前
wbp31发布了新的文献求助10
9秒前
1232112发布了新的文献求助10
10秒前
11秒前
宁静发布了新的文献求助30
11秒前
12秒前
RNNNLL发布了新的文献求助10
12秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974358
求助须知:如何正确求助?哪些是违规求助? 3518706
关于积分的说明 11195521
捐赠科研通 3254897
什么是DOI,文献DOI怎么找? 1797614
邀请新用户注册赠送积分活动 877011
科研通“疑难数据库(出版商)”最低求助积分说明 806128