维多利祖马布
医学
托法替尼
乌斯特基努马
内科学
炎症性肠病
科克伦图书馆
溃疡性结肠炎
纳塔利祖玛
克罗恩病
阿达木单抗
胃肠病学
肿瘤科
随机对照试验
疾病
类风湿性关节炎
作者
Elliot Berinstein,Jessica L. Sheehan,Janson Jacob,Claudia Steiner,Ryan W. Stidham,Carol Shannon,Shrinivas Bishu,Jacob Levine,Shirley Cohen‐Mekelburg,Akbar K. Waljee,Peter Higgins,Jeffrey Berinstein
标识
DOI:10.1007/s10620-023-07837-0
摘要
Dual targeted therapy (DTT) has emerged as an attractive therapeutic option for select patients with active inflammatory bowel disease (IBD) who are unable to achieve remission with biologic or small molecule monotherapy. We conducted a systematic review of specific DTT combinations in patients with IBD.We conducted a systematic search of MEDLINE, EMBASE, Scopus, CINAHL Complete, Web of Science Core Collection, and Cochrane Library to identify articles related to the use of DTT for the treatment of Crohn Disease (CD) or ulcerative colitis (UC) published before February 2021.Twenty-nine studies were identified comprising 288 patients started on DTT for partially or non-responsive IBD. We identified 14 studies with 113 patients receiving anti-tumor necrosis factor (TNF) and anti-integrin therapies (i.e., vedolizumab and natalizumab), 12 studies with 55 patients receiving vedolizumab and ustekinumab, nine studies with 68 patients receiving vedolizumab and tofacitinib, five studies with 24 patients receiving anti-TNF therapy and tofacitinib, six studies with 18 patients receiving anti-TNF therapy and ustekinumab, and three studies with 13 patients receiving ustekinumab and tofacitinib.DTT is a promising approach to improve IBD treatment for patients with incomplete responses to targeted monotherapy. Larger prospective clinical studies are needed to confirm these findings as is additional predictive modeling to identify the patient subgroups most likely to require and benefit from this approach.
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