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Age- and Sex-Specific Nomographic CT Quantitative Plaque Data From a Large International Cohort

医学 列线图 百分位 背景(考古学) 计算机断层血管造影 队列 内科学 易损斑块 计算机断层摄影 放射科 心脏病学 计算机断层摄影术 血管造影 古生物学 统计 生物 数学
作者
Γεώργιος Τζίμας,Gaurav S. Gulsin,Russell J. Everett,Mariama Akodad,David Meier,Kavishka Sewnarain,Zain Ally,Rawan Alnamasy,Nicholas Beng Hui Ng,Sarah Mullen,David C. Rotzinger,Janarthanan Sathananthan,Stephanie Sellers,Philipp Blanke,Jonathon Leipsic
出处
期刊:Jacc-cardiovascular Imaging [Elsevier BV]
卷期号:17 (2): 165-175 被引量:40
标识
DOI:10.1016/j.jcmg.2023.05.011
摘要

With growing adoption of coronary computed tomographic angiography (CTA), there is increasing evidence for and interest in the prognostic importance of atherosclerotic plaque volume. Manual tools for plaque segmentation are cumbersome, and their routine implementation in clinical practice is limited. The aim of this study was to develop nomographic quantitative plaque values from a large consecutive multicenter cohort using coronary CTA. Quantitative assessment of total atherosclerotic plaque and plaque subtype volumes was performed in patients undergoing clinically indicated coronary CTA, using an Artificial Intelligence-Enabled Quantitative Coronary Plaque Analysis tool. A total of 11,808 patients were included in the analysis; their mean age was 62.7 ± 12.2 years, and 5,423 (45.9%) were women. The median total plaque volume was 223 mm3 (IQR: 29-614 mm3) and was significantly higher in male participants (360 mm3; IQR: 78-805 mm3) compared with female participants (108 mm3; IQR: 10-388 mm3) (P < 0.0001). Total plaque increased with age in both male and female patients. Younger patients exhibited a higher prevalence of noncalcified plaque. The distribution of total plaque volume and its components was reported in every decile by age group and sex. The authors developed pragmatic age- and sex-stratified percentile nomograms for atherosclerotic plaque measures using findings from coronary CTA. The impact of age and sex on total plaque and its components should be considered in the risk-benefit analysis when treating patients. Artificial Intelligence-Enabled Quantitative Coronary Plaque Analysis work flows could provide context to better interpret coronary computed tomographic angiographic measures and could be integrated into clinical decision making.
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