视网膜色素上皮
细胞生物学
自噬
姜黄素
细胞内
代谢物
脂褐素
黄斑变性
内质网
视网膜
氧化应激
生物
化学
药理学
细胞凋亡
生物化学
医学
眼科
作者
Yi‐Hsiung Lin,Shwu‐Jiuan Sheu,Wangta Liu,Yun-Tzu Hsu,Chenxi He,Chang‐Yi Wu,Kuo‐Jen Chen,Po‐Yen Lee,Chien‐Chih Chiu,Kai‐Chun Cheng
出处
期刊:Phytomedicine
[Elsevier]
日期:2023-02-01
卷期号:110: 154606-154606
被引量:10
标识
DOI:10.1016/j.phymed.2022.154606
摘要
Age-related macular degeneration (AMD) is a disease of retinal pigment epithelium (RPE) cells. We have previously demonstrated that blue light can damage RPE cells and their underlying mechanisms. We found that hexahydrocurcumin (HHC), a metabolite of curcumin, had better retinal protection than curcumin. However, the involved mechanisms remain unclear.By exposing ARPE-19 human RPE cells and mouse primary RPE cells to blue light, the intracellular mechanisms of HHC in cells were investigated, including the proliferation of RPE cells and the effects of HHC on activating intracellular protective mechanisms and related factors. Next-generation sequencing (NGS) RNA sequencing revealed the underlying mechanisms involved in the induction and regulation of HHC treatment following blue light exposure.HHC promoted autophagy by enhancing autophagic flux, reduced oxidative stress and endoplasmic reticulum (ER) stress, and effectively reversed blue light-induced cell death. RNA sequencing-based bioinformatics approaches comprehensively analyze HHC-mediated cellular processes.Our findings elucidate the mechanisms of HHC against blue light damage in RPE cells and are beneficial for the development of natural metabolite-based preventive drugs or functional foods.
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