Dynamic Behavior of DNA Molecules in Microchannels: Exploring Deflective, Elliptical, and Spin Motions Induced by Saffman and Magnus Forces

物理 自旋(空气动力学) 纳米技术 凝聚态物理 经典力学 统计物理学 材料科学 热力学
作者
Zhiwei Li,Qiong Wang,Yong Niu,Ruiyu Wang,Wei Zhao,Chen Zhang,Guiren Wang,Kaige Wang
出处
期刊:Lab on a Chip [Royal Society of Chemistry]
卷期号:24 (15): 3704-3717
标识
DOI:10.1039/d4lc00140k
摘要

Precise manipulation of individual DNA molecules entering and leaving the channel ports, as well as their smooth passage across the channel, is essential for the detection and screening of DNA molecules using nano-/micro-fluidic technologies. In this paper, by combining single-molecule fluorescence imaging and numerical simulations, the motion states of DNA molecules translocating through a microfluidic channel under the action of the applied electric field are monitored and analyzed in detail. It is found that, under certain conditions of the applied electric field DNA molecules exhibit various motion states, including translation crossing, deflection outflow, reverse outflow, reciprocal movement, and elliptical movement. Simulations indicate that, under the action of Saffman force, DNA molecules can only undergo deflective motion when they experience a velocity gradient in the microchannel flow field; and they can only undergo elliptical motion when their deflective motion is accompanied by a spin motion. In this case, the Magnus force also plays an important role. The detailed study and elucidation of the movement states, dynamic characteristics and mechanisms of DNA molecules such as the deflective and elliptical motions under the actions of Saffman and Magnus forces have helpful implications for the development of related DNA/gene nano-/microfluidic chips, and for the separation, screening and detection of DNA molecules.
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